Massachusetts Medical Society: Interactive Question 6

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Interactive Question 6

May 28, 2013

 

Question:

 

Which of the following is/are important limitations of clopidogrel (Plavix)?

 

 

 

Answers

Answer:

reversible platelet inhibition
 

 

Correct Answer? 

 

Explanation:

Incorrect. Clopidogrel irreversibly blocks the adenosine diphosphate receptor.

 

Answers

Answer:

highest potency
 

 

Correct Answer? 

 

Explanation:

Incorrect. Clopidogrel appears to be less potent than the newer antiplatelet agent, ticagrelor, which is a reversible adenosine diphosphate receptor inhibitor.

 

Answers

Answer:

inter-individual variability in response
 

 

Correct Answer? 

 

Explanation:

Correct. Clopidogrel is a prodrug that requires a two-step activation processmediated mainly by the cytochrome P450 system. Genetic variation and drug-drug interactions may affect the extent to which clopidogrel is converted to its active form.

 

Answers

Answer:

lack of benefit in patients with acute coronary syndromes
 

 

Correct Answer? 

 

Explanation:

Incorrect.  Clopidogrel plus aspirin has been shown to be superior to aspirin alone in reducing cardiovascular event risk.

 

 

Format:

Radio buttons (single select)

 

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