Massachusetts Medical Society: Vaccination


The CDC recommends getting vaccinated if you were exposed to mpox (formerly monkeypox) or are at higher risk of being exposed to mpox. When properly administered before an exposure, vaccines are effective at protecting people against mpox. Mpox vaccination can be used as pre-exposure prophylaxis or post-exposure prophylaxis. JYNNEOSTM and ACAM2000 are the two currently licensed vaccines to prevent smallpox. To assist with the demand for vaccine, the FDA issued an emergency use authorization for the JYNNEOS vaccine to allow health care providers to use the vaccine by intradermal injection which will increase the total number of doses available for use by up to five-fold. ACAM2000 has a number of characteristics that may make it unsuitable for use in the current context, including considerably greater risk to the recipient compared with JYNNEOSTM. Data on both vaccines can be found on the CDC website. Read the CDC’s mpox and smallpox vaccine guidance. The Centers for Medicare & Medicaid Services have issued two new CPT codes effective July 26, 2022.

Massachusetts-specific mpox vaccination information:

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